The suspension of micronized Chromoglycate and propellants inside the container of the Spray Laríngeo Chromoglycate, together with the nasopharyngeal cannula, originated this brand new therapeutic product that permits the direct application and dosage on target organs in lower respiratory airways in sports equines.

Spray Laríngeo Chromoglycate inhibits both the immediate and non-immediate bronchoconstrictive reactions to inhaled antigen. It prevents bronchial hyper-reactivity and bronchospasm caused by exercise, toluene diisocyanate, aspirin, cold air, sulfur dioxide, and environmental pollutants.

Horses with lower respiratory airway inflammatory ailments: acute bronchial obstruction, SAID, RAD, COPD (chronic obstructive pulmonary diseases), EIPH (exercise induced pulmonare hemorrhage) or any of these diseases can keep on training with the application of Spray Laríngeo Chromoglycate by means of a flexible nasopharyngeal cannula.

Spray Laríngeo Chromoglycate is a desensitizer and inhibitor of the mechanisms that activate the bronchoconstrictive hyper-reaction that occur in equines presenting SAID, RAD, COPD (chronic obstructive pulmonary disease) including the exercise-induced bronchoconstriction, EIPH (exercise induced pulmonary hemorrhages) and other actions caused by allergens. It does not perform in the acute process, but after 3 to 4 weeks' treatment (twice a day) a desensitization is reached that lasts 4 days after withdrawal.

These sprayings are applied directly in the pharyngeal cavity with a flexible cannula through the nasal passages. The pharynx acts as an expansion chamber for the big drops to deposit thus permitting drops smaller than 3 microns stay in suspension be carried by the inspiratory flux into the lungs. This spray can also be applied intra-tracheally using a special needle accessory.

Spray Laríngeo Chromoglycate, due to its propelling force with fine drops, is the only device that allows the exact application and dosage on the bronchi and bronchioles. It has no intrinsic bronchodilator or antihistamine activity.

EASY TO USE

Shake the canister energetically. Introduce the cannula forward through the ventral meatus of the nasal cavity until reaching the pharynx (expansion zone), attach the canister, extend the horse's head, close the nostrils briefly to provoke a slight inspiration, let go and press for 2 seconds (one dose). Press again for another 2 seconds (second dose) with the next inspiration. This treatment must be performed in the morning and in the afternoon to reach the necessary desensitization and prevention.

FORMULA:

Micronized Sodium Chromoglycate 2.4 g
Excipients and propellants 65 g

THERAPEUTIC ACTION:

Spray Laríngeo Chromoglycate, when administered beforehand, acts as a non-corticoid anti-inflammatory that prevents mastcell degranulation. In allergic reactions and bronchial inflammation, it inhibits the release of mediators that trigger bronchial hyper-reactivity. A long-term application (3-4 weeks) helps control and prevent acute bronchial obstruction induced by exercise and produced by exposure to unspecific irritants that inhibit bronchial hyper-reactivity that cause bronchoconstriction. After withdrawal, the effect lasts for 3-4 days, notoriously improving breathing.

INDICATIONS:

Especially indicated in equines with a tendency for acute bronchial hyper-reactivity, SAID,RAD, COPD (chronic obstructive pulmonary disease), EIPH (exercise induced pulmonary hemorrhage), pulmonary emphysema, bronchoconstriction induced by exercise and other allergens that produce acute and chronic bronchial obstruction.

DOSAGE & ADMINISTRATION:

Introduce the cannula through the ventral meatus of the nasal cavity, into the pharynx. Close the nostrils to make the horse hold its breath for a short while, to induce a slight profound inspiration. Release, and when inspiration starts, push for 2 seconds, delivering a 40 mg. dose. Shake again and repeat the procedure in the next inspiration for 2 more seconds, thus completing the recommended 80 mg dose, twice a day (morning and afternoon) regularly for 3 to 4 weeks minimum.

After withdrawal, the desensitizing effect lasts for 4 days.

The pharynx and the trachea are used as an expansion chamber and deposit of the bigger particles, thus leaving those particles smaller than 3 microns in suspension, diminishing resistance (60%) from the upper respiratory airways, carrying the particles deep into the lungs by the inspiratory flux. Long term use significantly reduces bronchial hyper-reactivity that produces acute bronchial obstruction.

INTRATRACHEAL ACCESSORY:

If using the special intra-tracheal needle adapter, introduce the needle in any intercartilaginous area of the trachea with a 21 gauge x 1". The needle must be kept longitudinal to the trachea. Shake energetically and attach the Spray Laríngeo Chromoglycate canister (always vertical, the arrow pointing upwards) to the adapter.This featured accessory is for exclusive use by Veterinarians and is sold separately.

NOTICE FOR THE VETERINARIAN:

When applied for the first time, Chromoglycate may produce bronchoconstriction, therefore, in this case, we strongly recommend that a dose of Spray Laríngeo Salbutamol be given beforehand.

PRECAUTIONS:

The cannula and the adapter for the intra-tracheal needle must be cleaned using warm water, making it flow inside by means of a 21 gauge needle, after each application. Afterwards, shake the cannula to remove the excess water and leave to dry.

If blockage due to accumulation of Chromoglycate occurs, the spray will fail because the drug will not be delivered correctly in the accurate dose.

After use, proceed to disinfect the cannula/needle adapter.

Do not use the same cannula on different horses. Disinfect after each use. When taking the needle out of the trachea (a septic means) some microorganisms may deposit on the subcutaneous tissues.

THE FOLLOWING STEPS MUST BE FOLLOWED WHEN USING SPRAY LARINGEO CHROMOGLYCATE IN ORDER TO MAKE CERTAIN THAT THE CORRECT DOSAGE IS APPLIED. IT IS VERY IMPORTANT THAT THESE STEPS BE TAKEN TO INSURE THAT THE CHROMOGLYCATE REACHES THE BRONCHIOLES.

1. Spray Laríngeo Chromoglycate must be applied with the canister always held in upright vertical position (not inclined), with arrow on label pointing up.
2. Shake Laryngeal Spray Chromoglycate energetically.
3. Apply twitch to upper lip.
4. Place the head of the horse in the same line as the neck.
5. Connect the cannula to the canister.
6. Introduce half the cannula through one of the nostrils.
7. Cover nostrils to stop breathing for a short period of time in order to induce a slightly profound inspiration.
8. Shake again and introduce the cannula completely.
9. Release nostrils and when breathing begins, press pushbutton for 2 seconds, delivering a 40 mg. dose.
10. Extract the cannula halfway and shake again.
11. Reintroduce the cannula completely and apply 2 more seconds during the next inspiration, thus completing the dosage with a total of 80 mg.

The cannula and the adapter for the intra-tracheal needle must be washed through with a green cone needle (21 g) after use. Shake the cannula to remove excess water and leave out to dry, then disinfect.

The blockage caused by accumulation of medication could cause an incorrect dosage, therefore, it is important to keep the cannula and intra-tracheal adapter needle clean.